GLUT1, prostromal staining pattern. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo. Mei T, Wang Z, Wu J, Liu X, Tao W, Wang S, Chen F. Biomed Res Int. The overall 5-year survival rate following treatment for oral squamous cell carcinoma is around 50% in most published series. POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2005 Aug 20;116(2):253-62. doi: 10.1002/ijc.21008. Zedan W (1), Mourad MI (2), El-Aziz SM (3), Salamaa NM (4), Shalaby AA (5). A) GLUT1 membrane immunostaining in oral squamous cell carcinoma, 400×; B) GLUT1 expression in oral squamous cell carcinoma. Please enable it to take advantage of the complete set of features! Our results suggest that LAMP3 might act as a potential anticancer target and a prognostic marker in patients with OSCC. a) Kaplan –Meier curve of overall survival at five years in patients with OSCC (52.1%); b) Overall survival as a function of GLUT1 staining pattern (, Kaplan – Meier curve of disease - free survival as a function of GLUT3 staining pattern (. Accessibility Oral squamous cell carcinoma (OSCC) occasionally occurs in young patients and is likely to be distinct from OSCC in older patients. Epub 2020 Jun 10. Pereira KM, Feitosa SG, Lima AT, Luna EC, Cavalcante RB, de Lima KC, Chaves FN, Costa FW. Positive expression of GLUT 3 was associated with unfavorable free-disease survival (p = 0.021). Prognostic biomarkers in oral squamous cell carcinoma: A systematic review. eCollection 2020. National Library of Medicine Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. Recent research suggests that cancer stem cells (CSC) hold the key to … Oral squamous cell carcinoma (OSCC), the most common type of head and neck cancers, is associated with high recurrence, metastasis, low long-term survival rates and poor treatment outcome. Author information: GLUT 3 over expression was detected in 21.1% of OSCC cases. Introduction. FOIA 8600 Rockville Pike miR-23a-3p/SIX1 regulates glucose uptake and proliferation through GLUT3 in head and neck squamous cell carcinomas. Hence, this study investigated a battery of molecular markers that may help to reflect biologic aggressiveness and predict prognosis. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. Please enable it to take advantage of the complete set of features! Zhang X, Junior CR, Liu M, Li F, D'Silva NJ, Kirkwood KL. 2018 Jul 27;19(7):1779-1783. doi: 10.22034/APJCP.2018.19.7.1779. Would you like email updates of new search results? Wang H, Xue W, Ouyang W, Jiang X, Jiang X. J Cancer. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. Methods: 2003;15:1015–1024. POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma. Junction plakoglobin, a potential prognostic marker of oral squamous cell carcinoma, promotes proliferation, migration and invasion. 2014. doi: 10.1097/MD.0000000000005324. Shin M, Matsuo K, Tada T, Fukushima H, Furuta H, Ozeki S, Kadowaki T, Yamamoto K, Okamoto M, Jimi E. Carcinogenesis. See this image and copyright information in PMC. doi: 10.1097/00005537-200202000-00034. Oral cancer is a subset of head and neck cancers, which originates in the oral cavity [].At least 90% of oral cancers originate from squamous cells and are accordingly designated as oral squamous cell carcinoma (OSCC) [].Despite continuous advances in treatment strategies and diagnostic methods, the incidence and mortality rates associated with OSCC are increasing [3, 4]. A more molecular-based clinical staging and tailor-made therapy would benefit patients with bone invasion by OSCC. This site needs JavaScript to work properly. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. GLUT1, prostromal staining pattern. Epub 2011 Sep 1. D) and E) Basal staning pattern with the superficial layers showing little or no GLUT1 staining in the normal epithelium; F) GLUT1 immunostain (arrow). GLUT-1(+)/TKTL1(+) coexpression predicts poor outcome in oral squamous cell carcinoma. Most patients (63%) were non-smokers. Cancers (Basel). Involvement of GLUT1 and GLUT3 in the growth of canine melanoma cells. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. A more aggressive treatment modality and intensive follow-up may be recommended for the patients with reduced expression of in … Asian Pac J Cancer Prev. Bone resorption by osteoclasts is an important step in the process of bone invasion by oral SCCs. In the absence of squamous differentiation/keratinization: GLUT1 displays an antistromal pattern, suggestive of hipoxia-driven GLUT1 induction. Clinical-pathological features and overall survival data of 142 patients with Oral Squamous Cell Carcinoma (OSCC) were retrospectively reviewed from A.C.Camargo hospital records. TNFα and PTHrP) lead to receptor activator of NF-κB ligand (RANKL) expression or osteoprotegerin (OPG) suppression in oral SCC cells and in cancer stromal cells to induce osteoclastogenesis. Axl Is a Prognostic Marker in Oral Squamous Cell Carcinoma. Results: doi: 10.1002/(SICI)1097-0215(19990118)80:2<194::AID-IJC6>, Haber R.S., Rathan A., Weiser K.R., Pritsker A., Itzkowitz S.H., Bodian C., Slater G., Weiss A., Burstein D.E. Positive cell membrane GLUT 3 protein expression was associated with advanced clinic-staging of tumours (p = 0.005) as well as with vascular embolization (p = 0.005). Note positivity at periphery of…, a) Kaplan –Meier curve of overall survival at five years in patients with…, Kaplan–Meier curve of recurrence-free survival…. Oral Oncol, 49(9):923-931, 17 Apr 2013 Cited by: 53 articles | PMID: 23602254 Kallinowski F., Schlenger K.H., Runkel S., Kloes M., Stohrer M., Okunieff P., Vaupel P. Blood flow, metabolism, cellular microenvironment and growth rate of human tumor xenography. -. PubMed Abstract | CrossRef Full Text | Google Scholar Author information: (1)Jaipur Dental College and Hospital, Jaipur, India (University Affiliation: Maharaj Vinayak Global University, Jaipur, India). Cancer. COVID-19 is an emerging, rapidly evolving situation. -, Baer S., Casaubon L., Schwartz M.R., Macrogliese A., Younes M. GLUT 3 expression in biopsy specimens of laryngeal carcinoma is associated with poor survival. Kaplan – Meier curve of disease - free survival as a function of…, National Library of Medicine Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. doi: 10.1002/(SICI)1097-0142(19980701)83:1<34::AID-CNCR5>, Kunkel M., Reichert T.E., Benz P., Lehr H.A., Jeong J.H., Wieand S., Bartenstein P., Wagner W., Whiteside T.L. Tada T, Jimi E, Okamoto M, Ozeki S, Okabe K. Int J Cancer. 2014 Jun;117(6):743-53. doi: 10.1016/j.oooo.2014.02.007. Profiles of infiltrating immune cells and clinicopathological data were available for 78 OSCC patients with a median follow-up of 48 months. (2015) 15:743. doi: 10.1186/s12885-015-1727-6. Four pairs of tumor and adjacent normal tissues were collected from OSCC patients, and differentially expressed genes (DEGs) were screened via high-throughput RNA sequencing (RNA-seq). Over expression of GLUT 1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Immunohistochemical Investigation of Predictive Biomarkers for Mandibular Bone Invasion in Oral Squamous Cell Carcinoma. The cellular and molecular mechanisms of bone invasion by oral squamous cell carcinoma. 12. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Histopathology 72 , 905–913 (2018). Prognostic factors aid in the stratification and treatment of cancer. 2020 Oct;26(4):2381-2389. doi: 10.1007/s12253-020-00826-y. Oral squamous cell carcinoma (OSCC) is the most common oral cancer and has a poor prognosis. Ma H (1), Li L (1), Jia L (2), Gong A (1), Wang A (3), Zhang L (4), Gu M (5), Tang G (1). Bethesda, MD 20894, Copyright 1 … We aimed to identify new biomarkers or potential therapeutic targets for OSCC. Agnihotri NS(1), Astekar M(2). J. Immunhistochemical expression of GLUT1 is associated with low grade and low stage of urinary bladder cancer. These results demonstrate that TROP2 overexpression is an independent prognostic marker in patients with oral squamous cell carcinoma. 2016 Nov;95(45):e5324. Privacy, Help Tumorous and adjacent tissues were collected from … The progression of OPMD to OSCC is a multistep process that provides an opportunity for early cancer detection and interception. Bethesda, MD 20894, Copyright Epub 2012 Sep 16. Epub 2003 Oct 10. Prevention and treatment information (HHS). Jimi E, Furuta H, Matsuo K, Tominaga K, Takahashi T, Nakanishi O. 2002;112:393–396. TROP2 overexpression was detectable in 58% of the tumor samples, indicating it to be a potential novel therapeutic target in squamous cell carcinoma of the oral cavity. Oral Oncol. The objective of the study was to examine the prognostic value of hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase-IX (CA-IX), cyclooxygenase-2 (COX-2), Ki-67, and erythropoietin receptor in patients with oral tongue squamous cell carcinoma. 2020 Feb 10;11(9):2529-2539. doi: 10.7150/jca.30995. Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. -, Reisser C., Eichhorn K., Herold-Mende C., Born A.I., Bannasch P. Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol. 1989;49:3759–3764. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. 356 - 361 Article Download PDF View Record in Scopus Google Scholar Medicine (Baltimore). 8600 Rockville Pike eCollection 2021. Clipboard, Search History, and several other advanced features are temporarily unavailable. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. 1999;80:194–198. Several biological and molecular criteria have been established for making a prognosis of OSCC. Oral squamous cell carcinoma (OSCC) constitutes a large subgroup of head and neck squamous cell carcinoma and occupies more than 90% of … Epub 2010 Dec 23. Int J Clin Exp Pathol. Objectives . Note both GLUT1 expression: membrane and nucleus (arrows), 200×; C) GLUT3 membrane immunostaining in oral squamous cell carcinoma; D) No GLUT3 immunostaining. Materials and Methods . 2011 Jul;17(5):462-8. doi: 10.1111/j.1601-0825.2010.01781.x. A tissue microarray (TMA) was built for the immunohistochemical (IHC) analysis of GLUT 1 and GLUT 3. 2021 Feb 4;16(2):e0243859. 2004 Jan;31(1):5-12. doi: 10.1007/s00259-003-1316-9. Grimm M, Munz A, Teriete P, Nadtotschi T, Reinert S. Oral Surg Oral Med Oral Pathol Oral Radiol. Immunohistochemical Evaluation of GLUT-3 and GLUT-4 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma. Oral squamous cell carcinoma cells induce osteoclast differentiation by suppression of osteoprotegerin expression in osteoblasts. Careers. Haoran Ma 1*, Lijuan Li 1*, Lizhou Jia 2, Aixiu Gong 1, Aitao Wang 3, Lingli Zhang 4, … Privacy, Help Genome wide profiling in oral squamous cell carcinoma identifies a four genetic marker signature of prognostic significance Vui King Vincent-Chong, Iman Salahshourifar, In clinical practice, the main goal is to give the patient the treatment needed to cure the disease, but at the Oral Dis. 2020 Aug 29;2020:1682352. doi: 10.1155/2020/1682352. Tian M, Zhang H, Nakasone Y, Mogi K, Endo K. Eur J Nucl Med Mol Imaging. Feitosa SG, Viana KF, Luna ECM, Costa FWG, Cavalcante RB, Chaves FN, Chaves HV, Pereira KMA. Tumor markers of increased proliferation in oral carcinoma have been identified and explored for more than a decade now. Note also GLUT3 expression in the inflammatory cells, 200×. NCI CPTC Antibody Characterization Program. 2013 Feb;49(2):119-28. doi: 10.1016/j.oraloncology.2012.08.004. BMC Cancer. Tu XP, Qiu QH, Chen LS, Luo XN, Lu ZM, Zhang SY, et al. GLUT 1 Glucose transporter Expression in colorectal carcinoma: a marker for poor prognosis. 2019 Aug 1;12(8):3049-3057. eCollection 2019. Int. Squamous intraepithelial neoplasia, non- staining of basal layer. Bone invasion by oral squamous cell carcinoma: Molecular alterations leading to osteoclastogenesis - a review of literature. 2011 Nov;32(11):1634-40. doi: 10.1093/carcin/bgr198. Suwabe Y, Nakano R, Namba S, Yachiku N, Kuji M, Sugimura M, Kitanaka N, Kitanaka T, Konno T, Sugiya H, Nakayama T. PLoS One. GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells. Several biological and molecular criteria have been established for making a prognosis of OSCC. Note positivity at periphery of tumour nest, in non-keratinizing basaloid cells, and loss of GLUT1 expression accompanying keratinization at the centre of tumour nest, 200×; B) 400×; C) Non - keratinizing poorly differentiated carcinoma, 100×. Careers. Multidisciplinary Digital Publishing Institute (MDPI). Background: Oral squamous cell carcinoma (OSCC) is usually preceded by clinically visible changes on oral mucosa categorized as oral potentially malignant disorders (OPMD).
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